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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#_5 http://www.w3.org/ns/prov#value When WR19L was transformed with CD47, the transformants, after induction of apoptosis, could be phagocytosed by BAM3. Masking of the phosphatidylserine exposed on apoptotic thymocytes inhibited the engulfment, whereas the anti-SHPS-1 mAb inhibited not only the engulfment, but also the binding of apoptotic cells to phagocytes. These results indicate that macrophages require CD47 and phosphatidylserine on apoptotic cells for engulfment, and suggest that the interaction between CD47 and SHPS1 works as a tethering step in the phagocytosis. http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14634079 http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14634079 http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#_5 http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs#pubinfo http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs http://purl.org/dc/terms/created 2014-07-03T14:32:12.488+02:00 http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA0J_ZkJI56Eh5SmfotLKvvcRV23TBhgdoL7Yqmw0egUs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234