@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_head {
  this: np:hasAssertion dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_assertion;
    np:hasProvenance dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_provenance;
    np:hasPublicationInfo dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_assertion a np:Assertion .
  
  dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_provenance a np:Provenance .
  
  dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_publicationInfo
    a np:PublicationInfo .
}

dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_assertion {
  miriam-gene:2324 a ncit:C16612 .
  
  lld:C0027627 a ncit:C7057 .
  
  dgn-gda:DGNffc302bc7e8da6f19b32201ca4ddbd26 sio:SIO_000628 miriam-gene:2324, lld:C0027627;
    a sio:SIO_001121 .
}

dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_provenance {
  dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_assertion dcterms:description
      "[The promising therapeutic targets for osteosarcoma patients include: integrin, ezrin, statin, NOTCH/HES1, matrix metalloproteinases (MMPs), m-calpain, and Src, which are involved in tumor cell invasion and metastasis; aldolase A, fructose-bisphosphate, sulfotransferase family 3A, member 1, BCL2-associated athanogene 3, heat shock protein 70 (HSP70), B-cell lymphoma 2-interacting mediator (BIM), polo-like kinase 1, hypoxia inducible factor 1, alpha subunit, minibrain-related kinase, Bcl-xl, caspase-3, midkine, high mobility group box 1 protein (HMGB1), and Beclin1, which are involved in tumor proliferation and apoptosis; met proto-oncogene (hepatocyte growth factor receptor), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, insulin-like growth factor (IGF)-1R, fms-related tyrosine kinase 4, platelet-derived growth factor receptor, beta polypeptide, IGF-I/II, and c-kit, which are involved in tumor growth; endosialin, VEGF, thrombin, and MMPs, which are involved in tumor angiogenesis; transforming growth factor-α/β, parathyroid hormone-like hormone, interleukin-6, interleukin-11, receptor activator of nuclear factor-κB ligand, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, and cathepsin, which are involved in osteoclast function; Myc, HSP90, p-Met, p-Akt, p-STAT3, and cyclin D1, which are transcriptional factors; p-GP, hydroxysteroid (17-beta) dehydrogenase 10, HMGB1, BIM, inorganic phosphate, Bcl-2, PARP, mdm2, p21, Bax, and mitogen-activated protein kinase 1, which are involved in drug sensitivity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:23666471;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP1077055.RA0IaydA4YYuyUD_2otP1HHOatOmlrLEcgSA6j0fPVYdo130_publicationInfo {
  this: dcterms:created "2016-05-13T12:49:54+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}