@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA0DH304Ha8IAiVqRo8108mWYmCYtSOEVkrVyVaXKCRpE> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA0DH304Ha8IAiVqRo8108mWYmCYtSOEVkrVyVaXKCRpE#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasPart: sub:_2, sub:_3;
    a ProteinComplex: .
  
  sub:_2 geneProductOf: hgnc:8614;
    a Protein: .
  
  sub:_3 geneProductOf: hgnc:2681;
    a Protein: .
  
  sub:_4 occursIn: species:9606;
    rdf:object mesh:D017209;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "complex(p(HGNC:PAWR),p(HGNC:DAXX)) -> bp(MESHPP:Apoptosis)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "1.4" .
  
  sub:_5 prov:value "These findings suggest that Par-4, Daxx, and ZIPK may form a ternary complex, though further work is required to verify this hypothesis. ZIPK, Daxx, and Par-4 collaborate in caspase activation and apoptosis induction. Cells transfected individually with plasmids encoding ZIPK, Par-4, or Daxx did not exhibit an increase in apoptosis at the concentrations of plasmid DNA used here (Fig. 6A). In contrast, the percentage of apoptotic cells was increased two- to threefold in cultures of cells coexpressing ZIPK with either Par-4 or Daxx (Fig. 6A). Similarly, coexpressing Daxx with Par-4 elevated the percentage of apoptotic cells by two to threefold compared to the percentage due to expression of either Daxx or Par-4 alone (Fig. 6A). The most striking increase in apoptosis, however, was achieved by expressing all three proteins together. When expressed together, ZIPK, Daxx, and Par-4 induced an approximately sixfold increase in apoptosis.";
    prov:wasQuotedFrom pubmed:12917339 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12917339;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:15.523+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}