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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#_2 http://www.w3.org/ns/prov#value The establishment of the role of IL-18 in inflammation and RA led to the question of its angiogenic potential. In this study, we examined the capacity of IL-18 to mediate angiogenesis in in vitro and in vivo models. We further compared the angiogenic activity of IL-18 with that of known mediators, such as bFGF. One potential mechanism of the angiogenic activity of IL-18 that we examined is through the involvement of avb3 integrin (34). This role of avb3 was examined in the IL-18-induced migration of endothelial cells. IL-18 induced tube formation in Matrigel matrix in vitro. To examine the role of IL-18 in angiogenesis in vivo, we also implanted IL-18 in Matrigel plugs in mice, and found a significant increase in blood vessel formation over control, as measured by hemoglobin concentration. This effect was not decreased by implanting neutralizing anti-TNF-a Ab in the Matrigel plug. Finally, in an alternative model of angiogenesis, a wound granuloma model, we implanted sponge discs embedded with IL-18 into mice and showed a 4-fold increase in angiogenesis compared with controls. These findings support a novel role for IL-18 as an angiogenic mediator in RA and may elucidate a potential therapeutic target for angiogenesis-directed disease. http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11466388 http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11466388 http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#_2 http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s#pubinfo http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s http://purl.org/dc/terms/created 2014-07-03T14:31:42.780+02:00 http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA0BGP0zpCIzCLpaJp8NR9FkYoNNRM6kZAZCnayDLa06s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234