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[Targeting the single-nucleotide keratin 6a (K6a) N171K mutation responsible for the rare monogenic skin disorder pachyonychia congenita (PC), we demonstrate that small interfering RNAs (siRNAs) can potently and selectively block expression of mutant K6a.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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