dgn-np:NP61303.RA026PxkHiQKJVSrSJV7rIy_76PwPFrW367JfiUlMjGMM130_provenance {
  dgn-np:NP61303.RA026PxkHiQKJVSrSJV7rIy_76PwPFrW367JfiUlMjGMM130_assertion dcterms:description "[Systemic injection of KA (10 mg/kg, i.p.) caused seizures and increased the expression of neurotoxic markers, immediate early genes [c-jun, cyclooxygenase 2 (COX-2), brain-derived neurotrophic factor (BDNF), and heat shock protein 70 (hsp70)] and a delayed response gene [inducible nitric oxide synthase (iNOS)], which were measured at 6 and 72 h after KA injection, respectively, in the hippocampus.Pretreatment with Cp-Mn (50 mg/kg, i.p.) and DiAc-Cp-Mn (50 mg/kg, i.p.) but not with curcumin (50 mg/kg, i.p.) delayed the onset of KA-induced seizure without affecting the seizure score.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ;
    wi:evidence dgn-void:source_evidence_predicted ;
    sio:SIO_000772 miriam-pubmed:17827730 ;
    prov:wasDerivedFrom dgn-void:rgd-2016 ;
    prov:wasGeneratedBy eco:ECO_0000218 .
  dgn-void:rgd-2016 pav:importedOn "2016-01-25"^^xsd:date .
  dgn-void:source_evidence_predicted a eco:ECO_0000266 ;
    rdfs:comment "Gene-disease associations inferred from animal model manually asserted gene-disease associations."@en ;
    rdfs:label "DisGeNET evidence - PREDICTED"@en .
}