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http://www.informatics.jax.org/marker/MGI:99879
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p(MGI:Prkd1) -> p(MGI:Map2k3)
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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PKD induces activation of MAP kinases, MEK4 and MEK3, 6 activities, which are upstream activators of JNK and p38, respectively. BMP-2 also induced the activation of these MEKs and this effect was blunted in AS-PKD (PKD1 antisense mRNA) compared with empty vector-transfected cells suggesting that PKD is probably influencing either the regulation or the activity of a MEK kinase. Thus, BMP2 activated p38 MAPk via PKD through MEK3/6.
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Selventa
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2014-07-03T14:32:10.622+02:00
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