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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-hdW91wlL3S9IBaNQ5ulvn-A9QsZDaClq-4Rzy2wC40#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA-hdW91wlL3S9IBaNQ5ulvn-A9QsZDaClq-4Rzy2wC40#_3 http://www.w3.org/ns/prov#value Interestingly, expression of a constitutively active form of Akt causes spontaneous differentiation of 3T3-L1 cells.37 The experimental manipulation of cAMP, various G proteins, and protein kinase C isoforms have also been shown to affect adipogenesis in vitro.38 A more thorough knowledge of the critical extracellular signals involved in fat cell development would better enable us to place these findings in their appropriate context. Another environmental condition that affects adipogenesis is hypoxia, which inhibits the process. 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