sub:assertion { d:DB00559dv:ddi-interactor-indr:DB00559_DB00641 . d:DB00641dv:ddi-interactor-indr:DB00559_DB00641 . dr:DB00559_DB00641dct:identifier "drugbank_resource:DB00559_DB00641" ; dct:title "DDI between Bosentan and Simvastatin - Bosentan may decrease the serum concentration of simvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if bosentan is initiated, discontinued or dose changed."@en ; adv:Drug-Drug-Interaction ; rdfs:label "DDI between Bosentan and Simvastatin - Bosentan may decrease the serum concentration of simvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if bosentan is initiated, discontinued or dose changed. [drugbank_resource:DB00559_DB00641]"@en . }