http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#Head http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#assertion http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#provenance http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#pubinfo http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#assertion http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_1 http://purl.obolibrary.org/obo/RO_0002204 http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=69051 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0004237 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_1 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-diseases/cyclic%20stretch http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#assertion http://www.w3.org/2000/01/rdf-schema#label path(SDIS:"cyclic stretch") -> r(RGD:Tgfb1) http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_3 http://www.w3.org/ns/prov#value Vascular hypertrophy, which is characterized by proliferation of vascular smooth muscle cells (VSMC) and accumulation of extracellular matrix (ECM), is a major pathological change in blood vessels after chronic exposure to hypertension. Blood pressure is transmitted to the arterial walls and counterbalanced by mechanical stress, leading to stretching of circumferentially oriented VSMC, which may play some role in the pathogenesis of vascular hypertrophy. The present study was designed, therefore, to investigate the effect of mechanical stretch on the expression of ECM components and transforming growth factor-beta (TGF-beta), a potent stimulator for ECM production, and to examine the signal transduction mechanisms of the induction of TGF-beta in cultured rat VSMC. VSMC were subjected to cyclic stretch to provide a maximal elongation of 20% at a rate of 60 cycles per minute for up to 24 h. Mechanical stretch stimulated TGF-beta1 mRNA expression in a time- and elongation-dependent manner. http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10770255 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10770255 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#_3 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU#pubinfo http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU http://purl.org/dc/terms/created 2014-07-03T14:31:35.001+02:00 http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA-FnFexFsd8GNnmcZIPan54GInYNS3mVuKKmV7TaNpzU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234