. . . . . . . . . . . . . . . "p(HGNC:TNF) -> tscript(p(HGNC:HSF1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Fibroblast like synoviocytes were incubated with TNF-alpha(10ng/ml). TNF-alpha induced an hsp70 response, resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. TNF-alpha treated cells showed the formation of the hyperphosphorylated higher molecular weight isoform of HSF1. Activation of HSF1 by TNF-alpha was dose-dependent between 5 and 15 ng/ml of cytokine added to the cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3hours of cytokine incubation." . . "Selventa" . . . . "2014-07-03T14:31:00.107+02:00"^^ . . .