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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#_4 http://www.w3.org/ns/prov#value Cullin-1, a component of SCF, is modified by ubiquitin-like protein Nedd8. The modification site of cullin-1 was shown to be K696 because the K696R mutant was not modified. When the effect of the Nedd8 modification on the SCF(skp2) activity toward p27(kip1) was investigated, the activity was markedly decreased by using the Nedd8-unmodified mutant cullin-1 (K696R), indicating that the modification may play an important role on the SCF(skp2) activity toward p27(kip1). http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10772955 http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10772955 http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#_4 http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk#pubinfo http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk http://purl.org/dc/terms/created 2014-07-03T14:31:35.018+02:00 http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA-BJzCI37vNsJNkM4JjqxtPlAxdFUFdobi4yTrMJZFrk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234