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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#_3 http://www.w3.org/ns/prov#value Gicerin is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is reported that the human homologous molecule, CD146, is expressed in the endothelial cells. Here, we found that the expression of gicerin was increased in the rat carotid arteries after balloon injury. Immunohistochemical analysis demonstrated that the expression of gicerin protein was increased in the medial smooth muscle cells prior to the formation of neointima one week after the injury and was also increased in the luminal edge of the neointima after two weeks. We employed A10 cells, a cell line derived from rat aortic smooth muscle cell, and examined the effect of growth factors on the expression of gicerin, such as IGF-1, PDGF-BB, and bFGF. We found that IGF-1, but not PDGF-BB and bFGF, significantly increases the expression of gicerin protein in A10 cells. These suggest gicerin might be involved in the arteriosclerotic neointima formation in the artery. http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14706627 http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14706627 http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#_3 http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo#pubinfo http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo http://purl.org/dc/terms/created 2014-07-03T14:30:19.467+02:00 http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA-6hP50L1U6BQupRJrbEktefpIJSmuLTD_oCPr54Cfxo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234