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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-12qU9ivTHC4Cx6QPkiysYIFqOPxxlraYQ1yoD9eASg#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA-12qU9ivTHC4Cx6QPkiysYIFqOPxxlraYQ1yoD9eASg#_4 http://purl.org/dc/elements/1.1/identifier KEGG Info for PTEN http://www.tkuhn.ch/bel2nanopub/RA-12qU9ivTHC4Cx6QPkiysYIFqOPxxlraYQ1yoD9eASg#_4 http://purl.org/dc/elements/1.1/title KEGG Info for PTEN http://www.tkuhn.ch/bel2nanopub/RA-12qU9ivTHC4Cx6QPkiysYIFqOPxxlraYQ1yoD9eASg#_4 http://purl.org/dc/elements/1.1/type Other http://www.tkuhn.ch/bel2nanopub/RA-12qU9ivTHC4Cx6QPkiysYIFqOPxxlraYQ1yoD9eASg#_5 http://www.w3.org/ns/prov#value Entrez Gene summary: Rat: SUMMARY: may be involved in regulation of phosphoinositide 3-kinase and Akt kinase mediated antiapoptotic pathways [RGD] % ... Human: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. 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