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1 a reduction in the risk of aids defining illnesses or death 2 a prolonged suppression of hiv rna in all clinical studies with the exception of actg 32 the amplicor hiv monitor assay was used to determine the level of circulating hiv rna in serum this is an experimental use of the assay hiv rna results should not be directly compared to results from other trials using different hiv rna assays or using other sample sources study actg 32 was a multicenter randomized double blind clinical endpoint trial to compare the effect of crixivan in combination with zidovudine and lamivudine with that of zidovudine plus lamivudine on the progression to an aids defining illness adi or death patients were protease inhibitor and lamivudine naive and zidovudine experienced with cd4 cell counts of 2 cells mm 3 3 1 table 4 figures 1 2 table 4 actg 32 number of patients with aids defining illness or death endpoint idv zdv l zdv l idv indinavir zdv zidovudine l lamivudine hiv progression or death 35 6 1 63 1 9 death the number of deaths is inadequate to assess the impact of indinavir on survival 1 1 7 19 3 3 study actg 32 figure 1 indinavir protocol actg 32 zidovudine experienced plasma viral rna proportions below 4 copies ml study actg 32 figure 2 actg 32 zidovudine experienced cd4 cell counts mean change from baseline study 28 a double blind multicenter randomized clinical endpoint trial conducted in brazil compared the effects of crixivan plus zidovudine with those of crixivan alone or zidovudine alone on the progression to an adi or death and on surrogate marker responses all patients were antiretroviral naive with cd4 cell counts of 5 to 25 cells mm 3 3 1 table 5 figures 3 4 table 5 protocol 28 number of patients with aids defining illness or death endpoint idv zdv idv zdv hiv progression or death 21 6 3 27 8 1 62 18 7 death the number of deaths is inadequate to assess the impact of indinavir on survival 8 2 4 5 1 5 11 3 3 study 28 figure 3 indinavir protocol 28 zidovudine naive 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