. . . . . . . "[A reciprocal relationship exists between non-amyloidogenic and amyloidogenic APP processing such that impaired ADAM10-mediated proteolysis of the protein serves to enhance amyloidogenic processing (by beta- and gamma-secretases) thereby elevating levels of the amyloid beta (A beta)-peptides responsible for the neuronal death observed in the AD-afflicted brain.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:39+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .