@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAu0aqmbMLrSD47occp6IYRuudftCfMc8pGufw9mdkGpw> .
@prefix sub: <http://purl.org/np/RAu0aqmbMLrSD47occp6IYRuudftCfMc8pGufw9mdkGpw#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:association rdf:object <http://www.ebi.ac.uk/efo/EFO_0009854>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/DRUGBANK:DB01221>;
    a rdf:Statement;
    rdfs:label "Ketamine remains an off-label treatment for treatment-resistant depression with factors that limit widespread use including its dissociative effects and abuse potential.";
    biolink:association_type biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:cohort;
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/33155503/>;
    biolink:relation nkg:OffLabelIndication .
  
  sub:cohort rdfs:label "Adults";
    biolink:category biolink:Cohort .
  
  <http://www.ebi.ac.uk/efo/EFO_0009854> biolink:category biolink:Disease .
  
  <https://identifiers.org/DRUGBANK:DB01221> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "fnRU8fRI+l4d9tpE0qguzRu2hwXPinjZszdTTzIVRrngVjezkA2LymcMBFaJjSBzd72g7vMcwUC5HN9NFg5/MnAEv4qL7h8uVBr7uvZM9dTkDJHfT/byVv61WB0m8Ibp38mXNt9rrkg/8f46DGE09SzTcPhwd/NfN4eJG+va9RE=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-08-26T13:49:56.811+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-7641-6446;
    npx:supersedes <http://purl.org/np/RAQKsg6vORGUhneBuwHvRLzsF5iWSBbO5Un4lFLGWmd4I>;
    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>,
      <http://purl.org/np/RAjpBMlw3owYhJUBo3DtsuDlXsNAJ8cnGeWAutDVjuAuI>;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAZdZj78B6nKrP1Q00oFzsK07u7WdiY3sToz-H-H2nSgg> .
}