sub:assertion {
<
http://purl.obolibrary.org/obo/DOID_1787>
biolink:category biolink:Disease .
sub:association rdf:object <
http://purl.obolibrary.org/obo/DOID_1787> ;
rdf:predicate biolink:treats ;
rdf:subject <
https://identifiers.org/drugbank:DB00682> ;
a rdf:Statement ;
rdfs:label "\"Warfarin sodium is contraindicated in: Pregnancy Warfarin sodium is contraindicated in women who are pregnant except in pregnant women with mechanical heart valves, who are at high risk of thromboembolism [ see Warnings and Precautions (5.7) Use in Specific Populations (8.1 see Use in Specific Populations (8.1) Warfarin sodium is contraindicated in patients with: Hemorrhagic tendencies or blood dyscrasias Recent or contemplated surgery of the central nervous system or eye, or traumatic surgery resulting in large open surfaces [ see Warnings and Precautions (5.8) Bleeding tendencies associated with: - Active ulceration or overt bleeding of the gastrointestinal, genitourinary, or respiratory tract - Central nervous system hemorrhage - Cerebral aneurysms, dissecting aorta - Pericarditis and pericardial effusions - Bacterial endocarditis Threatened abortion, eclampsia, and preeclampsia Unsupervised patients with conditions associated with potential high level of non-compliance Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding Hypersensitivity to warfarin or to any other components of this product (e.g., anaphylaxis) [ see Adverse Reactions (6) Major regional or lumbar block anesthesia Malignant hypertension Pregnancy, except in women with mechanical heart valves. ( 4 5.7 8.1 Hemorrhagic tendencies or blood dyscrasias. ( 4 Recent or contemplated surgery of the central nervous system (CNS) or eye, or traumatic surgery resulting in large open surfaces. ( 4, 5.8) Bleeding tendencies associated with certain conditions. ( 4 Threatened abortion, eclampsia, and preeclampsia. ( 4 Unsupervised patients with potential high levels of non-compliance. ( 4 Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding. ( 4 Hypersensitivity to warfarin or any component of the product. ( 4 Major regional or lumbar block anesthesia. ( 4 Malignant hypertension. ( 4\"" ;
biolink:provided_by <
https://w3id.org/um/NeuroDKG> ;
biolink:relation schema:MedicalContraindication .
<
https://identifiers.org/drugbank:DB00682>
biolink:category biolink:Drug .
}