http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#Head http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc http://www.nanopub.org/nschema#hasAssertion http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#assertion http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc http://www.nanopub.org/nschema#hasProvenance http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#provenance http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc http://www.nanopub.org/nschema#hasPublicationInfo http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#pubInfo http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#assertion http://purl.obolibrary.org/obo/MONDO_0005414 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/biolink/vocab/Disease http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.obolibrary.org/obo/MONDO_0005414 http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate https://w3id.org/biolink/vocab/treats http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association http://www.w3.org/1999/02/22-rdf-syntax-ns#subject https://identifiers.org/DRUGBANK:DB00363 http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association http://www.w3.org/2000/01/rdf-schema#label There are no FDA or manufacturer guidelines for use of clozapine in pediatric population. Clozapine has been used in the treatment of refractory schizophrenia in child and adolescents. It is estimated that 40%–50% of patients with very early-onset schizophrenia (VEOS) are nonresponders to first-line neuroleptics and that clozapine is likely to be beneficial. http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association https://w3id.org/biolink/vocab/has_population_context http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#context http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association https://w3id.org/biolink/vocab/provided_by https://w3id.org/um/NeuroDKG http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association https://w3id.org/biolink/vocab/publications https://pubmed.ncbi.nlm.nih.gov/31082865 http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#association https://w3id.org/biolink/vocab/relation https://w3id.org/um/neurodkg/OffLabelIndication http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#context http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/biolink/vocab/Cohort http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#context http://www.w3.org/2000/01/rdf-schema#label Children and adolescents https://identifiers.org/DRUGBANK:DB00363 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/biolink/vocab/Drug http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#provenance http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#assertion http://www.w3.org/ns/prov#generatedAtTime 2021-08-24T16:18:41.079005 http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#pubInfo http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#sig http://purl.org/nanopub/x/hasAlgorithm RSA http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#sig http://purl.org/nanopub/x/hasPublicKey MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#sig http://purl.org/nanopub/x/hasSignature GqUg4WbHoU9uPwnxqgk/swfXVKdvzxdJhvJ9YY8E908HaMctgR1zdOu0KOZm4NCRze1WVBnw61HdI3QQEHjtl8Flyr8OkoX/F9jwt0xxiJvs084eotPo6kUMSDMHF0+qqOQAzmTTRP0NyeZLXsPvwID3/xXTVolVW+IPtBnz7Bw= http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc#sig http://purl.org/nanopub/x/hasSignatureTarget http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc http://www.w3.org/ns/prov#generatedAtTime 2021-08-24T16:18:41.079005 http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc http://www.w3.org/ns/prov#wasAttributedTo https://orcid.org/0000-0002-7641-6446 http://purl.org/np/RAsJA-5zi6dJjp4usxaEBKAWNaMX5Gm4A0SaEJ2tXX3Bc https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY