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[We then survey colon cancer cells with genetically engineered deficiencies in different DNMTs and find that the major activity against these substrates in extracts of these cells is DNMT1, with minor contribution from DNMT 3b and none from DNMT3a, the only known bona fide de novo methyltransferases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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