. . . . . . . "[Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical ?-secretase modulators affect the processing of APP by the ?-secretase complex and the production of the amyloid-beta peptide A?42, the accumulation of which is considered causative of Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:38+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .