https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#Head https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://www.nanopub.org/nschema#hasAssertion https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#assertion https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://www.nanopub.org/nschema#hasProvenance https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#provenance https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://www.nanopub.org/nschema#hasPublicationInfo https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#pubinfo https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#assertion https://doi.org/10.5061/dryad.gn219 http://purl.org/dc/terms/description High-throughput experimental methods such as medical sequencing and genome-wide association studies (GWAS) identify increasingly large numbers of potential relations between genetic variants and diseases. Both biological complexity (millions of potential gene-disease associations) and the accelerating rate of data production necessitate computational approaches to prioritize and rationalize potential gene-disease relations. Here, we use concept profile technology to expose from the biomedical literature both explicitly stated gene-disease relations (the explicitome) and a much larger set of implied gene-disease associations (the implicitome). Implicit relations are largely unknown to, or are even unintended by the original authors, but they vastly extend the reach of existing biomedical knowledge for identification and interpretation of gene-disease associations. The implicitome can be used in conjunction with experimental data resources to rationalize both known and novel associations. We demonstrate the usefulness of the implicitome by rationalizing known and novel gene-disease associations, including those from GWAS. To facilitate the re-use of implicit gene-disease associations, we publish our data in compliance with FAIR Data Publishing recommendations [https://www.force11.org/group/fairgroup] using nanopublications. An online tool (http://knowledge.bio) is available to explore established and potential gene-disease associations in the context of other biomedical relations. https://doi.org/10.5061/dryad.gn219 http://purl.org/dc/terms/publisher https://ror.org/00x6h5n95 https://doi.org/10.5061/dryad.gn219 http://purl.org/dc/terms/title Data from: The implicitome: a resource for rationalizing gene-disease associations https://doi.org/10.5061/dryad.gn219 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/dc/dcmitype/Dataset https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#provenance https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#assertion http://www.w3.org/ns/prov#wasAttributedTo https://orcid.org/0000-0002-4182-7560 https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#pubinfo https://orcid.org/0000-0002-4182-7560 http://xmlns.com/foaf/0.1/name Kristina Hettne https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#sig http://purl.org/nanopub/x/hasAlgorithm RSA https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#sig http://purl.org/nanopub/x/hasPublicKey MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCNRY+XQupJzQf9CyuI3/nPbXPBvBUnmhTPmcRzkndf2UR6pp5q+T+9xpB+7/hEWDr1IG25QxhCP0ZCQfAuXYhKcXboCzuWqw7Xw5bOXk31HYiogezYFVOpophOpoivkO0zXAu5CNTdB7+va3lWHWkHAL4yxcQdEzN0j/0SJrKgkwIDAQAB https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#sig http://purl.org/nanopub/x/hasSignature ewzSlwRAGqYuPwylyI7n5dTrSZC+zskiKCWr/s/l9N1ulsakTGbkUJFYOLwpUdr6bofCnzLeV23tTiavqhWjaQYUyuXI3iY/ndzTZ838hr9gsFLD85Y05czq4AXPuGW19D51cMk0+LVwpTqmh0Docfsly6EYJftFJGrTzb3JUWo= https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#sig http://purl.org/nanopub/x/hasSignatureTarget https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE#sig http://purl.org/nanopub/x/signedBy https://orcid.org/0000-0002-4182-7560 https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://purl.org/dc/terms/created 2024-04-11T15:15:27.244Z https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://purl.org/dc/terms/creator https://orcid.org/0000-0002-4182-7560 https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/4.0/ https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://purl.org/nanopub/x/hasNanopubType http://purl.org/dc/dcmitype/Dataset https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://purl.org/nanopub/x/wasCreatedAt https://nanodash.knowledgepixels.com/ https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE http://www.w3.org/2000/01/rdf-schema#label Dataset: Data from: The implicitome: a resource for rationalizing gene-disease associations https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate http://purl.org/np/RAh1gm83JiG5M6kDxXhaYT1l49nCzyrckMvTzcPn-iv90 https://w3id.org/np/RApNI026tOhVeSliPvddAxqblxM235VVQ5N6bvlzASNcE https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate http://purl.org/np/RAdvwtp0LfbKYtdCSVhZ2f52fdXqToOXv55TJY5NZcl8I