@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix this: <http://purl.org/np/RAoAA5b8Ye07n8lagOneMsxSG-m63sBR1lOaduJS-oMWY> .
@prefix sub: <http://purl.org/np/RAoAA5b8Ye07n8lagOneMsxSG-m63sBR1lOaduJS-oMWY#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0013600> a bl:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0013600>;
    rdf:predicate bl:treats;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00656>;
    a rdf:Statement;
    rdfs:label "Trazodone, the most sedating atypical antidepressant, is widely used as an off-label hypnotic especially in the elderly. Although generally considered safe, it can potentially inhibit midbrain dopaminergic neurotransmission leading to the emergence of extrapyramidal adverse effects. Two previous cases of trazodone-induced parkinsonism have been described after its prolonged use as an antidepressant; however, there is no published case of secondary parkinsonism caused by trazodone in a nondepressed person after its use as a hypnotic. Here, we present a case of rapid development of bradykinetic-rigid parkinsonism temporally linked to the use of trazodone as a hypnotic in a nondepressed elderly man";
    bl:has_population_context sub:context;
    bl:provided_by <https://w3id.org/um/NeuroDKG>;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/29634584>;
    bl:relation nkg:OffLabelIndication .
  
  sub:context a bl:Cohort;
    rdfs:label "elderly" .
  
  <https://identifiers.org/DRUGBANK:DB00656> a bl:Drug .
}

sub:provenance {
  sub:assertion prov:generatedAtTime "2021-08-26T09:32:54.334906"^^xsd:dateTime .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "EVuwjdgLFJ/uf9EwEKzPgxNL0H0B0AWwIzE5novhDdrt6pxYO2y73RQLUX/+OK+73/2Y/7Wl8Vdc7d1GH2sCoarZQS8Le387hO+h2/Gi8UVfI+5Tk5HuFrjKe8bfAREG78Dmzio+crlIJGvgOWdhRhnWYBmLe3GH+/UGYbcE50M=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2021-08-26T09:32:54.334906"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-7641-6446;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}