@prefix nt: <
https://w3id.org/np/o/ntemplate/
> .
@prefix orcid: <
https://orcid.org/
> .
@prefix bl: <
https://w3id.org/biolink/vocab/
> .
@prefix nkg: <
https://w3id.org/um/neurodkg/
> .
@prefix this: <
http://purl.org/np/RAoAA5b8Ye07n8lagOneMsxSG-m63sBR1lOaduJS-oMWY
> .
@prefix sub: <
http://purl.org/np/RAoAA5b8Ye07n8lagOneMsxSG-m63sBR1lOaduJS-oMWY#
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubInfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/MONDO_0013600
>
a
bl:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/MONDO_0013600
> ;
rdf:predicate
bl:treats
;
rdf:subject
<
https://identifiers.org/DRUGBANK:DB00656
> ;
a
rdf:Statement
;
rdfs:label
"Trazodone, the most sedating atypical antidepressant, is widely used as an off-label hypnotic especially in the elderly. Although generally considered safe, it can potentially inhibit midbrain dopaminergic neurotransmission leading to the emergence of extrapyramidal adverse effects. Two previous cases of trazodone-induced parkinsonism have been described after its prolonged use as an antidepressant; however, there is no published case of secondary parkinsonism caused by trazodone in a nondepressed person after its use as a hypnotic. Here, we present a case of rapid development of bradykinetic-rigid parkinsonism temporally linked to the use of trazodone as a hypnotic in a nondepressed elderly man" ;
bl:has_population_context
sub:context
;
bl:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
bl:publications
<
https://pubmed.ncbi.nlm.nih.gov/29634584
> ;
bl:relation
nkg:OffLabelIndication
.
sub:context
a
bl:Cohort
;
rdfs:label
"elderly" .
<
https://identifiers.org/DRUGBANK:DB00656
>
a
bl:Drug
.
}
sub:provenance
{
sub:assertion
prov:generatedAtTime
"2021-08-26T09:32:54.334906"^^
xsd:dateTime
.
}
sub:pubInfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
npx:hasSignature
"EVuwjdgLFJ/uf9EwEKzPgxNL0H0B0AWwIzE5novhDdrt6pxYO2y73RQLUX/+OK+73/2Y/7Wl8Vdc7d1GH2sCoarZQS8Le387hO+h2/Gi8UVfI+5Tk5HuFrjKe8bfAREG78Dmzio+crlIJGvgOWdhRhnWYBmLe3GH+/UGYbcE50M=" ;
npx:hasSignatureTarget
this:
.
this:
prov:generatedAtTime
"2021-08-26T09:32:54.334906"^^
xsd:dateTime
;
prov:wasAttributedTo
orcid:0000-0002-7641-6446
;
nt:wasCreatedFromTemplate
<
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY
> .
}