http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#Head
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
http://www.nanopub.org/nschema#hasAssertion
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#assertion
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
http://www.nanopub.org/nschema#hasProvenance
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#provenance
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
http://www.nanopub.org/nschema#hasPublicationInfo
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#pubinfo
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.nanopub.org/nschema#Nanopublication
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#assertion
http://purl.obolibrary.org/obo/DOID_10763
https://w3id.org/biolink/vocab/category
https://w3id.org/biolink/vocab/Disease
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#object
http://purl.obolibrary.org/obo/DOID_10763
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate
https://w3id.org/biolink/vocab/treats
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#subject
https://identifiers.org/drugbank:DB00678
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
http://www.w3.org/2000/01/rdf-schema#label
losartan potassium tablet usp is an angiotensin ii receptor blocker arb indicated for treatment of hypertension to lower blood pressure in adults and children greater than 6 years old lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events primarily strokes and myocardial infarctions 1 1 reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy there is evidence that this benefit does not apply to black patients 1 2 treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension 1 3 losartan potassium tablets usp are indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older to lower blood pressure lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular cv events primarily strokes and myocardial infarction these benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan control of high blood pressure should be part of comprehensive cardiovascular risk management including as appropriate lipid control diabetes management antithrombotic therapy smoking cessation exercise and limited sodium intake many patients will require more than 1 drug to achieve blood pressure goals for specific advice on goals and management see published guidelines such as those of the national high blood pressure education program s joint national committee on prevention detection evaluation and treatment of high blood pressure jnc numerous antihypertensive drugs from a variety of pharmacologic classes and with different mechanisms of action have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality and it can be concluded that it is blood pressure reduction and not some other pharmacologic property of the drugs that is largely responsible for those benefits the largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly elevated systolic or diastolic pressure causes increased cardiovascular risk and the absolute risk increase per mmhg is greater at higher blood pressures so that even modest reductions of severe hypertension can provide substantial benefit relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk so the absolute benefit is greater in patients who are at higher risk independent of their hypertension for example patients with diabetes or hyperlipidemia and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal some antihypertensive drugs have smaller blood pressure effects as monotherapy in black patients and many antihypertensive drugs have additional approved indications and effects e g on angina heart failure or diabetic kidney disease these considerations may guide selection of therapy losartan potassium tablets usp may be administered with other antihypertensive agents losartan potassium tablets usp are indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy but there is evidence that this benefit does not apply to black patients see use in specific populations 8 6 and clinical pharmacology 12 3 losartan potassium tablets usp are indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria urinary albumin to creatinine ratio 3 mg g in patients with type 2 diabetes and a history of hypertension in this population losartan potassium tablet usp reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease need for dialysis or renal transplantation see clinical studies 14 3
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
https://w3id.org/biolink/vocab/association_type
https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
https://w3id.org/biolink/vocab/provided_by
https://w3id.org/um/NeuroDKG
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#association
https://w3id.org/biolink/vocab/relation
https://schema.org/TreatmentIndication
https://identifiers.org/drugbank:DB00678
https://w3id.org/biolink/vocab/category
https://w3id.org/biolink/vocab/Drug
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#provenance
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#assertion
http://www.w3.org/ns/prov#wasAttributedTo
https://orcid.org/0000-0002-1468-3557
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#pubinfo
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#sig
http://purl.org/nanopub/x/hasAlgorithm
RSA
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#sig
http://purl.org/nanopub/x/hasPublicKey
MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#sig
http://purl.org/nanopub/x/hasSignature
HBGwAxLBeqSpBUCqnqZBerG05QlFBjSJkSvHooRhzwB/w1SRyt50XHtHCH0KTgZDONI4aRdfSzsKjnRbUjhDEc6Awj9n8CB/kXl2ZVYqY/A7hGS1Lw/5E5eSnRmtQA3C3dW+/GSSyXJUhkRWuUNfts3RAtUJEQ4/xP1kRTEkTz8=
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA#sig
http://purl.org/nanopub/x/hasSignatureTarget
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
http://purl.org/dc/terms/created
2021-06-27T19:57:25.087+02:00
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
http://purl.org/dc/terms/creator
https://orcid.org/0000-0002-1468-3557
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate
http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate
http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM
http://purl.org/np/RAm1N3XVLrnUPDbCsyK-RRoP8G70BZp4mxX0Nae0_sJtA
https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate
http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs