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[Of the four patients assayed, all developed anti-adenoviral antibodies.Adverse reactions associated with i.t. injection were mild, with no obvious correlation between the incidence, severity, or relationship of the events and drug dose. p53 gene therapy by i.t. injection of a replication-defective adenoviral expression vector is safe, feasible, and biologically effective (with respect to transduction frequency) in patients with either metastatic melanoma or breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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