. . . . . . . "[Here, we report that the natural product arctigenin from Arctium lappa (L.) can both inhibit A? production by suppressing ?-site amyloid precursor protein cleavage enzyme 1 expression and promote A? clearance by enhancing autophagy through AKT/mTOR signaling inhibition and AMPK/Raptor pathway activation as investigated in cells and APP/PS1 transgenic AD model mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:39+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .