[ { "@graph" : [ { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#pubInfo" } ] } ], "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#Head" }, { "@graph" : [ { "@id" : "https://uts.nlm.nih.gov/uts/umls/concept/C1707622", "http://wordnet-rdf.princeton.edu/lemma/integrate" : [ { "@id" : "https://uts.nlm.nih.gov/uts/umls/concept/C0871261" } ] } ], "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#assertion" }, { "@graph" : [ { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#assertion", "http://www.w3.org/ns/prov#generatedAtTime" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2021-12-16T19:29:10.646949" } ], "http://www.w3.org/ns/prov#wasGeneratedBy" : [ { "@value" : "S&T TWOC project version 2" } ] }, { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#version", "http://www.w3.org/ns/prov#value" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "2" } ] }, { "@id" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#OBJECT", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "into the final PK / PD model, \", where dexamethasone ( DEX ) exerted dexamethasone ( DEX ) s antitumor efficacy by inhibiting the proliferation of tumor cells\", enhanced dexamethasone ( DEX ) responses by decreasing the sensitivity parameter EC(50 )" } ] }, { "@id" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#OBJECT-POSITION", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "191" } ] }, { "@id" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#PREDICATE", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "integrated" } ] }, { "@id" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#PREDICATE-POSITION", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "[154]" } ] }, { "@id" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#SUBJECT", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "The PK model of dopamine D(2)-like receptor ( D2DR ) antagonist sulpiride ( SUL ) as well as that of dexamethasone ( DEX ) with a time-dependent clearance" } ] }, { "@id" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#SUBJECT-POSITION", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "45" } ] }, { "@id" : "http://www.w3.org/2000/01/rdf-schema#ABSTRACT-UID", "http://twoc-nlp-database-server-1:8555/solr/triples/select?fl=TRIPLE_UID,%20CORD_UID,%20SUBJECT,%20PREDICATE,%20WORDNET_SEMREL,%20%20OBJECT,%20PRED_POSITION,%20SUBJECT_CUIS,%20OBJECT_CUIS,%20UMLS_SEMREL,%20PRED_POSITION,%20PREDICATE-LEMMA&q=CORD_UID:wdxnfuun&rows=50" : [ { "@value" : "wdxnfuun" } ] }, { "@id" : "http://www.w3.org/2000/01/rdf-schema#SENTENCE", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "The PK model of dopamine D(2)-like receptor (D2DR) antagonist sulpiride (SUL) as well as that of dexamethasone (DEX) with a time-dependent clearance were integrated into the final PK/PD model both using Hill’s function, where dexamethasone (DEX) exerted dexamethasone (DEX)'s antitumor efficacy by inhibiting the proliferation of tumor cells, and dopamine D(2)-like receptor (D2DR) antagonist sulpiride (SUL) enhanced dexamethasone (DEX) responses by decreasing the sensitivity parameter EC(50)." } ] }, { "@id" : "http://www.w3.org/2000/01/rdf-schema#TRIPLE-UID", "http://twoc-nlp-database-server-1:8555/solr/triples/select?q=TRIPLE_UID:wdxnfuun-TRIPLE-ABSTRACT-10" : [ { "@value" : "wdxnfuun-TRIPLE-ABSTRACT-10" } ] }, { "@id" : "https://uts.nlm.nih.gov/uts/umls/concept/C0871261", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "responses" } ] }, { "@id" : "https://uts.nlm.nih.gov/uts/umls/concept/C1707622", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "d2dr" } ] } ], "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#provenance" }, { "@graph" : [ { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0", "http://www.w3.org/ns/prov#generatedAtTime" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2021-12-16T19:29:10.646949" } ], "http://www.w3.org/ns/prov#wasAttributedTo" : [ { "@id" : "https://orcid.org/0000-0002-8954-0470" } ] }, { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#assertion", "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470835/" } ] }, { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#sig", "http://purl.org/nanopub/x/hasAlgorithm" : [ { "@value" : "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey" : [ { "@value" : "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCSLeezU8JYlBsrgXOGXX4fxOq4oydsMzMK1CN0Rez2OEd2IYk18R4DetcZXwGhN3Pil7qcgNkiGvTirJXIo8zHl7jVehs19EdYtrttCKEaXRzWIr4LuCrfGedkvonEMWqR8e1GdQsLgEEyM50BD6Qw+srQt9ozcqf/9wG2MAMX9QIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature" : [ { "@value" : "WGRiPo4Hyq8NFukA4AIPoPG3pKzxcg6SwvXfXLs1XrlhA6HTJfFXbyGicGnyM+BYE1iTouDLKHVwSseqL2lZHcb8tmrQGSi3IGYL82nrqqQKhDPdNnMZpzo1JVu9XeRCJsZNLSa3vX2L6KUXQpYkFLFBL47uMDkq/M/fQUXryZo=" } ], "http://purl.org/nanopub/x/hasSignatureTarget" : [ { "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0" } ] } ], "@id" : "http://purl.org/np/RAk9greBcI6D-IZaF20eG33Va8T2pl1TK0P1FV2YRzIt0#pubInfo" } ]