@prefix biolink: <
https://w3id.org/biolink/vocab/
> .
@prefix ns1: <
https://w3id.org/np/o/ntemplate/
> .
@prefix this: <
http://purl.org/np/RAibbhN7-pBTHpqLrZjZ-kS8gQF0I8rsWpra8jNe0AVjs
> .
@prefix sub: <
http://purl.org/np/RAibbhN7-pBTHpqLrZjZ-kS8gQF0I8rsWpra8jNe0AVjs#
> .
@prefix schema: <
https://schema.org/
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix dct: <
http://purl.org/dc/terms/
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix orcid: <
https://orcid.org/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/DOID_13884
>
biolink:category
biolink:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/DOID_13884
> ;
rdf:predicate
biolink:treats
;
rdf:subject
<
https://identifiers.org/drugbank:DB00489
> ;
a
rdf:Statement
;
rdfs:label
"\"SORINE (sotalol hydrochloride) tablets are contraindicated in patients with: Sinus bradycardia, sick sinus syndrome, second and third degree AV block, unless a functioning pacemaker is present Congenital or acquired long QT syndromes Cardiogenic shock or decompensated heart failure Serum potassium <4 mEq/L Bronchial asthma or related bronchospastic conditions Hypersensitivity to sotalol For the treatment of AFIB/AFL, SORINE (sotalol hydrochloride) tablets are also contraindicated in patients with: Baseline QT interval >450 ms Creatinine clearance <40 mL/min For the treatment of AFIB/AFL or ventricular arrhythmias Sinus bradycardia, 2 nd rd 4 Congenital or acquired long QT syndrome ( 4 Serum potassium <4 mEq/L( 4 Cardiogenic shock, decompensated heart failure ( 4 Bronchial asthma or related bronchospastic conditions ( 4 Hypersensitivity to sotalol ( 4 For the treatment of AFIB/AFL also contraindicated for: QT interval >450 ms ( 4 Creatinine clearance <40 mL/min ( 4\"" ;
biolink:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
biolink:relation
schema:MedicalContraindication
.
<
https://identifiers.org/drugbank:DB00489
>
biolink:category
biolink:Drug
.
}
sub:provenance
{
sub:assertion
prov:wasAttributedTo
orcid:0000-0002-1468-3557
.
}
sub:pubinfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" ;
npx:hasSignature
"VSHPKdmtZp4YPGIzA5Vilm3iE46WumMcSAEqbDV9Pen8Q7CHQDPZLPhwuP3jRFizxYx+WOnLVaF/kPls8usdKif2zqEh6YYcJFmdBfFOtvQ4UQyqqKOkWw9Xjvk1HbrrIUSJqNb0AeZcZnut2WEbxXTDYdFSFwbgR6sC4CNcCMA=" ;
npx:hasSignatureTarget
this:
.
this:
dct:created
"2021-08-23T12:23:16.631+02:00"^^
xsd:dateTime
;
dct:creator
orcid:0000-0002-1468-3557
;
ns1:wasCreatedFromProvenanceTemplate
<
http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM
> ;
ns1:wasCreatedFromPubinfoTemplate
<
http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM
> ;
ns1:wasCreatedFromTemplate
<
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY
> .
}