@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix this: <http://purl.org/np/RAayHgg0rwyy3VekvzOBUQRTWgFievCUPaLwH4aLWhYO4> .
@prefix sub: <http://purl.org/np/RAayHgg0rwyy3VekvzOBUQRTWgFievCUPaLwH4aLWhYO4#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_1574> a bl:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_1574>;
    rdf:predicate bl:treats;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00334>;
    a rdf:Statement;
    rdfs:label "Olanzapine was FDA approved for the treatment of schizophrenia and bipolar disorder only. It is an atypical antagonist of D2 and D4 receptors which determines a decrease in craving for alcohol. The DRD4 gene of dopamine presents a VNTR polymorphism, with a number of repetitions that varies from 2 to 11 which allows for the division of individuals in two subgroups: those with a number of repetitions between 2 and 6, classified as DRD4 S and those with more than 7 repetitions, classified as DRD4 L. Association studies between this variation and AUD have showed that individuals who carry the L allele exhibit greater craving after alcohol intake,50. Another study has investigated the association olanzapine-DRD4 showing that olanzapine reduces craving to the L allele carriers only, while no benefits were observed in S allele carriers.";
    bl:has_population_context sub:context;
    bl:provided_by <https://w3id.org/um/NeuroDKG>;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/29912214>;
    bl:relation nkg:OffLabelIndication .
  
  sub:context a bl:Cohort;
    rdfs:label "adults" .
  
  <https://identifiers.org/DRUGBANK:DB00334> a bl:Drug .
}

sub:provenance {
  sub:assertion prov:generatedAtTime "2021-08-26T09:18:29.198055"^^xsd:dateTime .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "Xul0Er1OEZlq+dVjbQ0m1pCd5STdOYyyHJARC23oqe/5lhRL5V1pr6zj39fii3udiM/oFfnA67tJ2ToNRVXdbaWJ1UlSjx04RpgdSwAQUQcNm57ILUyuwyImpyCBmkQ4q1t5r9ie/+FSFHAXAtrok87vzn6Aarb0u4QuYXZyhV4=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2021-08-26T09:18:29.198055"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-7641-6446;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}