. . . . . . . "[Recent advances show that proinflammatory mediators in Paneth cell dense core secretory granules mediate tumor necrosis factor-?-induced shock, that Paneth cell ?-defensins modulate the composition of the small intestinal microflora, that development of crypt organoid culture systems provides a novel means for investigating the crypt microenvironment, and that varied genetic defects that disrupt Paneth cell homeostasis are emergent as risk factors in inflammatory bowel disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:16:46+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .