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[In addition, emerging research using AD postmortem brains and AD mouse models revealed that VDAC1 is linked to A? and phosphorylated tau, blocks the mitochondrial permeability transition (MPT) pores, disrupts the transport of mitochondrial proteins and metabolites, impairs gating of VDAC, and causes defects in oxidative phosphorylation, leading to mitochondrial dysfunction in AD neurons.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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