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[Metformin treatment dynamically regulated the CD44(pos)CD24(neg/low) breast cancer stem cell immunophenotype, transcriptionally reprogrammed cells through decreased expression of key drivers of the EMT machinery including the transcription factors ZEB1, TWIST1 and SNAI2 (Slug) and the pleiotrophic cytokines TGF?s, and lastly impeded the propensity of breast cancer stem cells to form multicellular 'microtumors' in non-adherent and non-differentiating conditions (i.e., 'mammospheres').]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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