@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAV-uYtAmJH2lGwVWQDa-0-4zmHVvAfZfTeSvq8TvQyOQ> .
@prefix sub: <http://purl.org/np/RAV-uYtAmJH2lGwVWQDa-0-4zmHVvAfZfTeSvq8TvQyOQ#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_3393> biolink:category biolink:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_3393>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/drugbank:DB00952>;
    a rdf:Statement;
    rdfs:label "\"Naratriptan tablets are contraindicated in patients with:      Ischemic coronary artery disease (CAD) (angina pectoris, history of myocardial infarction, or documented silent ischemia) or coronary artery vasospasm, including Prinzmetal's angina [see    Warnings and Precautions (5.1)  ]     Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders [see    Warnings and Precautions (5.2)  ]     History of stroke or transient ischemic attack (TIA) or history of hemiplegic or basilar migraine because such patients are at a higher risk of stroke [see    Warnings and Precautions (5.4)  ]     Peripheral vascular disease [see    Warnings and Precautions (5.5)  ]     Ischemic bowel disease [see    Warnings and Precautions (5.5)  ]     Uncontrolled hypertension [see    Warnings and Precautions (5.8)  ]     Recent use (i.e., within 24 hours) of another 5-HT  1  agonist, ergotamine-containing medication, ergot-type medication (such as dihydroergotamine or methysergide) [see    Drug Interactions  (7.1, 7.2)]     Hypersensitivity to naratriptan (angioedema and anaphylaxis seen) [see    Warnings and Precautions   (5.9)]     Severe renal or hepatic impairment [see    Use in Specific Populations  (8.6, 8.7),    Clinical Pharmacology   (12.3)]     History of coronary artery disease or coronary artery vasospasm (4)  Wolff-Parkinson-White syndrome or other cardiac accessory conduction pathway disorders (4)  History of stroke, transient ischemic attack, or hemiplegic or basilar migraine (4)  Peripheral vascular disease (4)  Ischemic bowel disease (4)  Uncontrolled hypertension (4)    Recent (within 24 hours) use of another 5-HT  1  agonist (e.g., another triptan) or an ergotamine-containing medication (4)  Hypersensitivity to naratriptan (angioedema and anaphylaxis seen) (4)  Severe renal or hepatic impairment (4)\"";
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:relation schema:MedicalContraindication .
  
  <https://identifiers.org/drugbank:DB00952> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "bwa6+y4PCAIPfPKOhAyb7wKM7cxcR9Xjm9OT2Rj5+7nGLjda8LVOqgl5YHrWokVGmeK0vgrsWNYo3R1hVPu50qGi7GMFStP5ttW+ZrirW3/pyQGxD1H8q7t0TPX+Ki9VfrG7a9sDZ79rW5XgARuE4PaSagmd1bTt03qpJMChqP0=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-08-23T18:30:22.832+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-1468-3557;
    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}