@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix ns1: <http://www.w3.org/ns/prov#> .
@prefix this: <http://purl.org/np/RAUxFHwgJkYySZCCrC_Q-icfdFen2FCOZ4RsHE8OKT-I0> .
@prefix sub: <http://purl.org/np/RAUxFHwgJkYySZCCrC_Q-icfdFen2FCOZ4RsHE8OKT-I0#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   <http://purl.obolibrary.org/obo/DOID_0050426> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_0050426> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB01285> ;
    a rdf:Statement ;
    rdfs:label "acthar gel is indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age 1 1 acthar gel is indicated for the treatment of exacerbations of multiple sclerosis in adults 1 2 acthar gel may be used for the following disorders and diseases rheumatic collagen dermatologic allergic states ophthalmic respiratory and edematous state 1 3 1 9 acthar gel repository corticotropin injection is indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age acthar gel repository corticotropin injection is indicated for the treatment of acute exacerbations of multiple sclerosis in adults controlled clinical trials have shown acthar gel to be effective in speeding the resolution of acute exacerbations of multiple sclerosis however there is no evidence that it affects the ultimate outcome or natural history of the disease as adjunctive therapy for short term administration to tide the patient over an acute episode or exacerbation in psoriatic arthritis rheumatoid arthritis including juvenile rheumatoid arthritis selected cases may require low dose maintenance therapy ankylosing spondylitis during an exacerbation or as maintenance therapy in selected cases of systemic lupus erythematosus systemic dermatomyositis polymyositis severe erythema multiforme stevens johnson syndrome serum sickness severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as keratitis iritis iridocyclitis diffuse posterior uveitis and choroiditis optic neuritis chorioretinitis anterior segment inflammation symptomatic sarcoidosis to induce a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopathic type or that due to lupus erythematosus" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:relation schema:TreatmentIndication .
  <https://identifiers.org/drugbank:DB01285> bl:category bl:Drug .
}
sub:provenance {
   sub:assertion ns1:wasAttributedTo orcid:0000-0002-1468-3557 .
}
sub:pubinfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" ;
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    npx:hasSignatureTarget this: .
  this: dcterms:created "2021-07-03T14:49:45.714+02:00"^^xsd:dateTime ;
    dcterms:creator orcid:0000-0002-1468-3557 ;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM> ;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM> ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}