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[Plasma levels of tartrate-resistant acid phosphatase (TRAP), receptor activator of nuclear-?B (RANK) ligand and Runt-related transcription factor 2 (Runx2/Cbfa1) exhibited a significant correlation to the severity of aortic stenosis. mRNA levels in normal, thickened and calcified parts of aortic valves assessed by quantitative real-time PCR were significantly elevated in calcified parts of valves for TRAP (5.08 � 1.6-fold, P<0.001) RANK ligand (8.6 � 4.2-fold, P<0.001) and RANK (1.98 � 0.78-fold, P=0.015).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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