. . . . . . . "[In this study, we further characterize the interactions between Hb and A? in vitro and in vivo and report the following observations: 1) the binding of Hb to A? required iron-containing heme; 2) other heme-containing proteins, such as myoglobin and cytochrome C, also bound to A?; 3) hemin-induced cytotoxicity was reduced in neuroblastoma cells by low levels of A?; 4) Hb was detected in neurons and glial cells of post-mortem AD brains and was up-regulated in aging and APP/PS1 transgenic mice; 5) microinjection of human Hb into the dorsal hippocampi of the APP/PS1 transgenic mice induced the formation of an envelope-like structure composed of A? surrounding the Hb droplets.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:38+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .