@prefix bl: . @prefix nkg: . @prefix nt: . @prefix orcid: . @prefix this: . @prefix sub: . @prefix np: . @prefix rdf: . @prefix xsd: . @prefix rdfs: . @prefix prov: . @prefix npx: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubInfo; a np:Nanopublication . } sub:assertion { a bl:Disease . sub:association rdf:object ; rdf:predicate bl:treats; rdf:subject ; a rdf:Statement; rdfs:label "Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019)."; bl:has_population_context sub:context; bl:provided_by ; bl:publications ; bl:relation nkg:OffLabelIndication . sub:context a bl:Cohort; rdfs:label "Adults" . a bl:Drug . } sub:provenance { sub:assertion prov:generatedAtTime "2021-08-16T20:58:13.507487"^^xsd:dateTime . } sub:pubInfo { sub:sig npx:hasAlgorithm "RSA"; npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB"; npx:hasSignature "jKLO3KFJt18DL3cYPb+vZaEjaIhModY//TQW+rSIG0zZoHcW4GZiWjt2Bmt7r78z09kHRMn1Wu8wc/vNX+e7ufwBCmSIsWD9HoG0HPdAKeoDJk3iip4bR1EkpLeNHOgBHXadwvfc0SmToPX4qzlOrEw4COr92C1sJw0q9W6G4Ow="; npx:hasSignatureTarget this: . this: prov:generatedAtTime "2021-08-16T20:58:13.507487"^^xsd:dateTime; prov:wasAttributedTo orcid:0000-0002-7641-6446; nt:wasCreatedFromTemplate . }