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[The results show the remarkable fact that acute pharmacological activation of GK reverses secretion defects of ?-cells caused by molecular mechanism that differ vastly in nature, including the little understood multifactorial lesion of ?-cells in T2DM of man, the complex GK mutations in mice resembling GK disease and acute sulphonylurea failure of mouse ?-cells in tissue culture.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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