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[Here, we show that bone marrow-derived M-CSF-dependent macrophages (BMMs) from the heterozygous cherubism mutant (Sh3bp2(KI/+) ) mice are highly responsive to TNF-? and can differentiate into osteoclasts independently of RANKL in vitro by a mechanism that involves spleen tyrosine kinase (SYK) and phospholipase C?2 (PLC?2) phosphorylation, leading to increased nuclear translocation of NFATc1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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