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[Moreover, we show that concurrent loss/inhibition of Tpl2 kinase (Cot, Map3k8), a MAP3K that is recruited to activated CD40 complex and regulates macrophage activation/cytokine production, potentiated direct, ex vivo anti-myeloma tumoricidal activity of ?CD40+CpG-activated macrophages, promoted production of antitumor cytokine IL12 in vitro and in vivo, and synergized with ?CD40+CpG to further prolong PFS and OS in vivo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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