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[In the cytokine cascade, a central position is occupied by that molecule known as 'cachectin' or 'tumor necrosis factor,' because this molecule, more than any other, has been shown to mediate the biologic effects of LPS, and to provoke a state of wasting very similar to that observed in cancer cachexia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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