http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#Head
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
http://www.nanopub.org/nschema#hasAssertion
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#assertion
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
http://www.nanopub.org/nschema#hasProvenance
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#provenance
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
http://www.nanopub.org/nschema#hasPublicationInfo
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#pubInfo
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.nanopub.org/nschema#Nanopublication
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#assertion
http://purl.obolibrary.org/obo/MONDO_0005277
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/biolink/vocab/Disease
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#object
http://purl.obolibrary.org/obo/MONDO_0005277
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate
https://w3id.org/biolink/vocab/treats
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#subject
https://identifiers.org/DRUGBANK:DB00321
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
http://www.w3.org/2000/01/rdf-schema#label
Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019).
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
https://w3id.org/biolink/vocab/has_population_context
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#context
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
https://w3id.org/biolink/vocab/provided_by
https://w3id.org/um/NeuroDKG
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
https://w3id.org/biolink/vocab/publications
https://pubmed.ncbi.nlm.nih.gov/31622593
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association
https://w3id.org/biolink/vocab/relation
https://w3id.org/um/neurodkg/OffLabelIndication
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#context
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/biolink/vocab/Cohort
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#context
http://www.w3.org/2000/01/rdf-schema#label
Adults
https://identifiers.org/DRUGBANK:DB00321
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/biolink/vocab/Drug
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#provenance
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#assertion
http://www.w3.org/ns/prov#generatedAtTime
2021-08-16T20:58:07.416019
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#pubInfo
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#sig
http://purl.org/nanopub/x/hasAlgorithm
RSA
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#sig
http://purl.org/nanopub/x/hasPublicKey
MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#sig
http://purl.org/nanopub/x/hasSignature
B7/KcuKQi6BEqCraWTskyVjmw0gI0NtvNM2px5+bjTLJMo/yPfB9MqN0kB4zsDflH+qsOZ2O5gID7R0//A4PjIuXVxWZt0wNAts1c9DhpuNzp92GJX6kJuCg0+3a4rjQhUUeYcaf9MQegnE7M1u5YuC/dZDPYgiymKf4ryDPYjw=
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#sig
http://purl.org/nanopub/x/hasSignatureTarget
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
http://www.w3.org/ns/prov#generatedAtTime
2021-08-16T20:58:07.416019
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
http://www.w3.org/ns/prov#wasAttributedTo
https://orcid.org/0000-0002-7641-6446
http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8
https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY