[ {
  "@graph" : [ {
    "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#pubinfo"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#Head"
}, {
  "@graph" : [ {
    "@id" : "http://purl.obolibrary.org/obo/DOID_594",
    "https://w3id.org/biolink/vocab/category" : [ {
      "@id" : "https://w3id.org/biolink/vocab/Disease"
    } ]
  }, {
    "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#association",
    "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://purl.obolibrary.org/obo/DOID_594"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "https://w3id.org/biolink/vocab/treats"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "https://identifiers.org/drugbank:DB00404"
    } ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "alprazolam tablets are indicated for the management of anxiety disorder a condition corresponding most closely to the apa diagnostic and statistical manual dsm iii r diagnosis of generalized anxiety disorder or the short term relief of symptoms of anxiety anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic generalized anxiety disorder is characterized by unrealistic or excessive anxiety and worry apprehensive expectation about two or more life circumstances for a period of six months or longer during which the person has been bothered more days than not by these concerns at least 6 of the following 18 symptoms are often present in these patients trembling twitching or feeling shaky muscle tension aches or soreness restlessness easy fatigability shortness of breath or smothering sensations palpitations or accelerated heart rate sweating or cold clammy hands dry mouth dizziness or light headedness nausea diarrhea or other abdominal distress flushes or chills frequent urination trouble swallowing or lump in throat feeling keyed up or on edge exaggerated startle response difficulty concentrating or mind going blank because of anxiety trouble falling or staying asleep irritability these symptoms must not be secondary to another psychiatric disorder or caused by some organic factor motor tension autonomic hyperactivity vigilance and scanning anxiety associated with depression is responsive to alprazolam alprazolam tablets are also indicated for the treatment of panic disorder with or without agoraphobia studies supporting this claim were conducted in patients whose diagnoses corresponded closely to the dsm iii r criteria for panic disorder see clinical studies panic disorder is an illness characterized by recurrent panic attacks the panic attacks at least initially are unexpected later in the course of this disturbance certain situations eg driving a car or being in a crowded place may become associated with having a panic attack these panic attacks are not triggered by situations in which the person is the focus of others attention as in social phobia the diagnosis requires four such attacks within a four week period or one or more attacks followed by at least a month of persistent fear of having another attack the panic attacks must be characterized by at least four of the following symptoms dyspnea or smothering sensations dizziness unsteady feelings or faintness palpitations or tachycardia trembling or shaking sweating choking nausea or abdominal distress depersonalization or derealization paresthesias hot flashes or chills chest pain or discomfort fear of dying fear of going crazy or of doing something uncontrolled at least some of the panic attack symptoms must develop suddenly and the panic attack symptoms must not be attributed to some know organic factors panic disorder is frequently associated with some symptoms of agoraphobia demonstrations of the effectiveness of alprazolam by systematic clinical study are limited to four months duration for anxiety disorder and four to ten weeks duration for panic disorder however patients with panic disorder have been treated on an open basis for up to eight months without apparent loss of benefit the physician should periodically reassess the usefulness of the drug for the individual patient"
    } ],
    "https://w3id.org/biolink/vocab/association_type" : [ {
      "@id" : "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation"
    } ],
    "https://w3id.org/biolink/vocab/provided_by" : [ {
      "@id" : "https://w3id.org/um/NeuroDKG"
    } ],
    "https://w3id.org/biolink/vocab/relation" : [ {
      "@id" : "https://schema.org/TreatmentIndication"
    } ]
  }, {
    "@id" : "https://identifiers.org/drugbank:DB00404",
    "https://w3id.org/biolink/vocab/category" : [ {
      "@id" : "https://w3id.org/biolink/vocab/Drug"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#assertion",
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "https://orcid.org/0000-0002-1468-3557"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2021-07-03T14:17:16.812+02:00"
    } ],
    "http://purl.org/dc/terms/creator" : [ {
      "@id" : "https://orcid.org/0000-0002-1468-3557"
    } ],
    "https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate" : [ {
      "@id" : "http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM"
    } ],
    "https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate" : [ {
      "@id" : "http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM"
    } ],
    "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate" : [ {
      "@id" : "http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs"
    } ]
  }, {
    "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#sig",
    "http://purl.org/nanopub/x/hasAlgorithm" : [ {
      "@value" : "RSA"
    } ],
    "http://purl.org/nanopub/x/hasPublicKey" : [ {
      "@value" : "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB"
    } ],
    "http://purl.org/nanopub/x/hasSignature" : [ {
      "@value" : "FR33Su08cyPAcfmuoDgNu4vOwpJmnGVI57VTkGa/PRh2pKHoz0U9IRXL3B5XLqtc7YK6YRs0Neb5FkIfoCIi6XOZCZYoJpJFQ02h/qx5BN9kVHMvJpjVWjQRJSqaJ7nLP7AGPdyfWcucFQAJ498Om8l2ShdaEarFBHSWPR+sd20="
    } ],
    "http://purl.org/nanopub/x/hasSignatureTarget" : [ {
      "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAKXC8nu5o_IY2KyjqkGeOdFaq3Q3et_Hm87sHX6Zh8a4#pubinfo"
} ]