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[Importantly, our results further showed that HupA inhibited GSK3?/? activity, and enhanced the ?-catenin level in the transgenic mouse brain and in SH-SY5Y cells overexpressing Swedish mutation APP, suggesting that the neuroprotective effect of HupA is not related simply to its AChE inhibition and antioxidation, but also involves other mechanisms, including targeting of the Wnt/?-catenin signaling pathway in AD brain.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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