[ { "@graph" : [ { "@id" : "http://rdf.disgenet.org/resource/gda/DGN45e162534dfb398f343bf9b59a0a0c45", "@type" : [ "http://semanticscience.org/resource/SIO_001121" ], "http://semanticscience.org/resource/SIO_000628" : [ { "@id" : "http://identifiers.org/ncbigene/7124" }, { "@id" : "http://linkedlifedata.com/resource/umls/id/C0032231" } ] } ], "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#assertion" }, { "@graph" : [ { "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#publicationInfo" } ] } ], "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#head" }, { "@graph" : [ { "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#assertion", "http://purl.org/dc/terms/description" : [ { "@language" : "en", "@value" : "[We show here that K5NOSepiLMW, an O-sulphated heparin-like semi-synthetic polymer of the D-glucuronic acid-N-acetyleparoson disaccharide unit with low molecular weight, has marked anti-inflammatory effects in a rat model of acute inflammation, the carrageenan-induced pleurisy, commonly used to test NSAID efficacy.A 30-min. pre-treatment with K5NOSepiLMW (0.1, 0.5 and 1 mg/kg b.wt., given intrapleurally) attenuated the recruitment of leucocytes in the lung tissue and the pleural exudate, inhibited the induction of inducible nitric oxide synthase and cyclooxygenase-2 (COX-2), thereby abating the generation of nitric oxide and pro-inflammatory prostaglandins such as PgE(2) and PGF(1alpha), reduced the inflammation-induced nitroxidative lung tissue injury, as shown by tissue thiobarbituric acid-reactive substances and nitrotyrosine, and blunted the local generation of cytokines such as interleukin-1beta and tumour necrosis factor-alpha.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." } ], "http://purl.org/ontology/wi/core#evidence" : [ { "@id" : "http://rdf.disgenet.org/v5.0.0/void/source_evidence_predicted" } ], "http://semanticscience.org/resource/SIO_000772" : [ { "@id" : "http://identifiers.org/pubmed/20141620" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://rdf.disgenet.org/v5.0.0/void/RGD" } ], "http://www.w3.org/ns/prov#wasGeneratedBy" : [ { "@id" : "http://purl.obolibrary.org/obo/ECO_0000218" } ] }, { "@id" : "http://rdf.disgenet.org/v5.0.0/void/RGD", "http://purl.org/pav/importedOn" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#date", "@value" : "2017-01-25" } ] }, { "@id" : "http://rdf.disgenet.org/v5.0.0/void/source_evidence_predicted", "@type" : [ "http://purl.obolibrary.org/obo/ECO_0000266" ], "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@language" : "en", "@value" : "Gene-disease associations inferred from animal model manually asserted gene-disease associations." } ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@language" : "en", "@value" : "DisGeNET evidence - PREDICTED" } ] } ], "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#provenance" }, { "@graph" : [ { "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2017-10-17T13:16:48+02:00" } ], "http://purl.org/dc/terms/rights" : [ { "@id" : "http://opendatacommons.org/licenses/odbl/1.0/" } ], "http://purl.org/dc/terms/rightsHolder" : [ { "@id" : "http://rdf.disgenet.org/v5.0.0/void/IBIGroup" } ], "http://purl.org/dc/terms/subject" : [ { "@id" : "http://semanticscience.org/resource/SIO_000983" } ], "http://purl.org/net/provenance/ns#usedData" : [ { "@id" : "http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://orcid.org/0000-0001-5999-6269" }, { "@id" : "http://orcid.org/0000-0002-7534-7661" }, { "@id" : "http://orcid.org/0000-0002-9383-528X" }, { "@id" : "http://orcid.org/0000-0003-0169-8159" }, { "@id" : "http://orcid.org/0000-0003-1244-7654" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0003-0169-8159" } ], "http://purl.org/pav/version" : [ { "@value" : "v5.0.0.0" } ] }, { "@id" : "http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf", "http://purl.org/pav/version" : [ { "@value" : "v5.0.0" } ] } ], "@id" : "http://rdf.disgenet.org/resource/nanopub/NP1036470.RAIyZ_Lv1T43H4VqH8glva2azOkHFtE8tyDiGlw5b6ujw#publicationInfo" } ]