sub:provenance {
sub:assertion dcterms:description "[We show here that K5NOSepiLMW, an O-sulphated heparin-like semi-synthetic polymer of the D-glucuronic acid-N-acetyleparoson disaccharide unit with low molecular weight, has marked anti-inflammatory effects in a rat model of acute inflammation, the carrageenan-induced pleurisy, commonly used to test NSAID efficacy.A 30-min. pre-treatment with K5NOSepiLMW (0.1, 0.5 and 1 mg/kg b.wt., given intrapleurally) attenuated the recruitment of leucocytes in the lung tissue and the pleural exudate, inhibited the induction of inducible nitric oxide synthase and cyclooxygenase-2 (COX-2), thereby abating the generation of nitric oxide and pro-inflammatory prostaglandins such as PgE(2) and PGF(1alpha), reduced the inflammation-induced nitroxidative lung tissue injury, as shown by tissue thiobarbituric acid-reactive substances and nitrotyrosine, and blunted the local generation of cytokines such as interleukin-1beta and tumour necrosis factor-alpha.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ;
wi:evidence dgn-void:source_evidence_predicted ;
sio:SIO_000772 miriam-pubmed:20141620 ;
prov:wasDerivedFrom dgn-void:RGD ;
prov:wasGeneratedBy eco:ECO_0000218 .
dgn-void:RGD pav:importedOn "2017-01-25"^^
xsd:date .
dgn-void:source_evidence_predicted a eco:ECO_0000266 ;
rdfs:comment "Gene-disease associations inferred from animal model manually asserted gene-disease associations."@en ;
rdfs:label "DisGeNET evidence - PREDICTED"@en .
}