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[Hyperinsulinaemia and hyperglycaemia exerted independent effects with similar direction of modulation on PI3KR1 (phosphatidylinositol 3-kinase, regulatory 1), LXR? (liver X receptor ?), PDK4 (pyruvate dehydrogenase kinase 4) and FOXO1 (forkhead box O1A) and produced an additive effect on PI3KR1, the gene that encodes the p85? subunit of PI3K in human skeletal muscle.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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