@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix ns1: <http://www.w3.org/ns/prov#> .
@prefix this: <http://purl.org/np/RAEXlhtka0sWqDGxkfaPZ5kozaD96IfOpkMMKI4aH7Os8> .
@prefix sub: <http://purl.org/np/RAEXlhtka0sWqDGxkfaPZ5kozaD96IfOpkMMKI4aH7Os8#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_8567> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_8567> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB08870> ;
    a rdf:Statement ;
    rdfs:label "adcetris is a cd3 directed antibody drug conjugate indicated for treatment of adult patients with previously untreated stage iii or iv classical hodgkin lymphoma chl in combination with doxorubicin vinblastine and dacarbazine 1 1 classical hodgkin lymphoma chl at high risk of relapse or progression as post autologous hematopoietic stem cell transplantation auto hsct consolidation 1 2 classical hodgkin lymphoma chl after failure of auto hsct or after failure of at least two prior multi agent chemotherapy regimens in patients who are not auto hsct candidates 1 3 previously untreated systemic anaplastic large cell lymphoma salcl or other cd3 expressing peripheral t cell lymphomas ptcl including angioimmunoblastic t cell lymphoma and ptcl not otherwise specified in combination with cyclophosphamide doxorubicin and prednisone 1 4 systemic anaplastic large cell lymphoma salcl after failure of at least one prior multi agent chemotherapy regimen 1 5 primary cutaneous anaplastic large cell lymphoma pcalcl or cd3 expressing mycosis fungoides mf who have received prior systemic therapy 1 6 adcetris is indicated for the treatment of adult patients with previously untreated stage iii or iv chl in combination with doxorubicin vinblastine and dacarbazine adcetris is indicated for the treatment of adult patients with chl at high risk of relapse or progression as post autologous hematopoietic stem cell transplantation auto hsct consolidation adcetris is indicated for the treatment of adult patients with chl after failure of auto hsct or after failure of at least two prior multi agent chemotherapy regimens in patients who are not auto hsct candidates adcetris is indicated for the treatment of adult patients with previously untreated salcl or other cd3 expressing ptcl including angioimmunoblastic t cell lymphoma and ptcl not otherwise specified in combination with cyclophosphamide doxorubicin and prednisone adcetris is indicated for the treatment of adult patients with salcl after failure of at least one prior multi agent chemotherapy regimen adcetris is indicated for the treatment of adult patients with pcalcl or cd3 expressing mf who have received prior systemic therapy" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:relation schema:TreatmentIndication .
  <https://identifiers.org/drugbank:DB08870> bl:category bl:Drug .
}
sub:provenance {
  sub:assertion ns1:wasAttributedTo orcid:0000-0002-1468-3557 .
}
sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" ;
    npx:hasSignature "WImQ4v4cYgPava3wn/U00F+zkAZScY+5lpGGJP3feXQHEujl7OPjX54IBfnHV7meMVssTRLnI4JdqJOmqu45qFk90HwvAduYkX6Na85pfd8B1QgNYb4lgFUazz6b2SUy88Oec1jPIPlAs4ncgtVMZweu2ly6TQVdllaXYCniZ2Y=" ;
    npx:hasSignatureTarget this: .
  this: dcterms:created "2021-07-03T14:58:06.103+02:00"^^xsd:dateTime ;
    dcterms:creator orcid:0000-0002-1468-3557 ;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM> ;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM> ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}