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episodes of bipolar i disorder two 3 to 4 week trials and one maintenance trial 14 2 adolescents ages 13 17 efficacy was established in one 3 week trial in patients with manic or mixed episodes associated with bipolar i disorder 14 2 1 2 medication therapy for pediatric patients with schizophrenia or bipolar i disorder should be undertaken only after a thorough diagnostic evaluation and with careful consideration of the potential risks 1 3 adjunct to valproate or lithium in the treatment of manic or mixed episodes associated with bipolar i disorder 1 2 efficacy was established in two 6 week clinical trials in adults 14 2 as zyprexa intramuscular for the treatment of acute agitation associated with schizophrenia and bipolar i mania 1 4 efficacy was established in three 1 day trials in adults 14 3 as zyprexa and fluoxetine in combination for the treatment of depressive episodes associated with bipolar i disorder 1 5 efficacy was established with symbyax olanzapine and fluoxetine in combination in adults refer to the product label for symbyax treatment of treatment resistant depression major depressive disorder in patients who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode 1 6 efficacy was established with symbyax olanzapine and fluoxetine in combination in adults refer to the product label for symbyax oral zyprexa is indicated for the treatment of schizophrenia efficacy was established in three clinical trials in adult patients with schizophrenia two 6 week trials and one maintenance trial in adolescent patients with schizophrenia ages 13 17 efficacy was established in one 6 week trial see clinical studies 14 1 when deciding among the alternative treatments available for adolescents clinicians should consider the increased potential in adolescents as compared with adults for weight gain and hyperlipidemia clinicians should consider the potential long term risks when prescribing to adolescents and in many cases this may lead them to consider prescribing other drugs first in adolescents see warnings and precautions 5 5 5 6 monotherapy see clinical studies 14 2 when deciding among the alternative treatments available for adolescents clinicians should consider the increased potential in adolescents as compared with adults for weight gain and hyperlipidemia clinicians should consider the potential long term risks when prescribing to adolescents and in many cases this may lead them to consider prescribing other drugs first in adolescents see warnings and precautions 5 5 5 6 adjunctive therapy to lithium or valproate see clinical studies 14 2 pediatric schizophrenia and bipolar i disorder are serious mental disorders however diagnosis can be challenging for pediatric schizophrenia symptom profiles can be variable and for bipolar i disorder pediatric patients may have variable patterns of periodicity of manic or mixed symptoms it is recommended that medication therapy for pediatric 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